A chance encounter with a mysterious stranger (Joe Manganiello) points Pee-wee toward his destiny -- and his first-ever holiday!

In "Pee-wee's Big Holiday," lovable oddball Pee-wee Herman, played by Paul Reubens, lives a predictable life in Fairville until a chance meeting with actor Joe Manganiello sparks his sense of adventure.

Determined to attend Joe's birthday party in New York City, Pee-wee embarks on a cross-country road trip filled with absurd escapades. As he encounters eccentric characters, quirky challenges, and outlandish scenarios, Pee-wee's journey becomes a whirlwind of hilarity and heartwarming moments.