After news reporter Danny Tanner's wife Pam is killed in a car crash by a drunk driver, he recruits his brother-in-law Jesse (an exterminator turned rock musician) and quirky best friend Joey (who works as a stand-up comedian) to help raise his three daughters, D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.