Dr. Daniel Pierce is an eccentric neuropsychiatrist who uses his unique outlook to help the federal government solve complex criminal cases.

Perception Is a dramatic series starring Eric McCormack as Dr. Daniel Pierce, a forensic neuroscientist who assists the FBI with solving crimes in between teaching at a Chicago university. When former student and colleague, Special Agent Kate Moretti (Rachael Leigh Cook) hires him as a consultant, the eccentric Pierce uses his expertise in human behavior to help crack some of Chicago's most complex cases.

But throughout the process he finds himself relying more and more on his schizophrenia-induced hallucinations for guidance. Sometimes his best friend Natalie Vincent (Kelly Rowan) helps him think his cases through, while others, like his teaching assistant Max Lewicki (Arjay Smith) and Dean Paul Haley (played by LeVar Burton) help him see the difference between reality, and what only he perceives as real.